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A series of mixed, generalized linear models were conducted to look for differences between the CRWP and placebo groups for the physiological assessments

Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

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Glutathione is an incredibly important substance in the body that helps with detoxification and protects against oxidative damage