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All the AGS + SiNP treatments decreased the GR activity from 46 U/g FW in C to 24 U/g FW and below, the most significant decrease being recorded in the case of AGS + 4% SiNP treatment (V4)

Notably, enzymes governing polyamine biosynthesis, including glutamic oxaloacetic transaminase 2 (GOT2), aminoacylase-1 (ACY1), ODC, and SDS, exhibit overexpression in prostate cancer, while ornithine aminotransferase (OAT) demonstrates insufficient expression (66)

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10 The primary role of GLP-1s is glucose and weight regulation, but the cardiovascular findings point to a broader impact on long-term health