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This knowledge has paved the way for the development of personalized medicine approaches that target cancer-initiating cells, offering new hope for improved treatment outcomes [524]

They are categorized based on the type of sapogenin as either triterpenoid or steroidal and occur in great amounts in medicinal plants, pulses, cereals, and spices

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Typically, cells contain a spectrum of endogenous antioxidant enzymes, such as GSH, GPX, SOD, CAT, PRX, and Trx, which can directly scavenge dangerous ROS (hydroxyl radicals, peroxyl radicals, superoxides, and lipid peroxides) and maintain intracellular redox homeostasis [45, 46]