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Sorafenib can inhibit the expression of SLC7A11 and activate the downstream ferroptosis pathway with its own RAF kinase inhibitor effect ( Osteosarcoma Osteosarcoma is the most common primary bone malignant tumor, which is common in young people

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10,17 The pain, together with joint stiffness and reduced range of motion, promotes functional deterioration and limited mobility, which significantly affect the quality of life