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Transactivation of NRF2 in KO livers was further supported by constitutive induction of NRF2 target genes, including Gclc , metallothionein I ( Mt1 ) and heme-oxgenase 1 ( Hmox1) (Fig

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The interaction between microglia and astrocytes, particularly the activation of neuroprotective A2 astrocytes, could further contribute to mitigating neuroinflammation and restoring neural homeostasis

Starting at 2.5mg weekly, increasing to 5mg after four weeks, then 7.5mg, 10mg, 12.5mg, and potentially 15mg based on response and tolerance

In ciliary body and retinal wall, levels of proinflammatory enzymes iNOS and COX-2 and activation of PKC and NF-B were also reduced in groups that underwent benfotiamine treatment [13]

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