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doi: 10.1111/tpj.14410 115 YamajiN.XiaJ.Mitani-UenoN.YokoshoK.Feng MaJ

Mitochondrial dysfunction in ocular disease: focus on glaucoma

In contrast, glycolysis-driven subpopulations can evade metabolic stress by reprogramming their metabolism through FAO and glutamine utilization, giving rise to highly treatment-resistant cellular subsets [125]

Accumulation of ethanol-associated reactive molecules, e.g., reactive oxygen (ROS) and nitrogen species (RNS), and electrophilic products, e.g., acetaldehyde and lipid peroxidation-derived products, can be harmful to biological systems due to their propensity to inactivate enzymes, leading to loss of protein function, DNA damage and cell death 4

This can lead to neurodegenerative diseases such as Alzheimers and Parkinsons