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Preclinical studies demonstrate that tirzepatide promotes healthy adipose tissue expansion (hyperplasia rather than hypertrophy), increases adiponectin secretion, and enhances lipid uptake into adipocytes effectively improving the "metabolic sink" function of fat tissue

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If these measures are insufficient, optimizing dopaminergic medication according to the individual risk profile, as well as alpha-2-delta ligands or opioids may be considered [38, 201]