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Amyloid -mediated ROS production was reported to induce lipid peroxidation, causing impaired membrane permeability and activating excitotoxicity mechanisms because of increased calcium (Ca 2+ ) influx

Neither compound has an FDA-approved use, so there is no regulatory efficacy or safety determination to lean on

It is speculated that iron deficiency may limit the activity of iron-dependent tyrosine hydroxylase, thereby weakening dopaminergic signal transmission, which is also a core pathophysiological feature of ADHD

To further delineate the specific structural domain of MAT2A responsible for its association with SRF, we constructed a series of truncation mutants: MAT2A-1 (aa 270), MAT2A-2 (aa 71330), and MAT2A-3 (aa 331395)

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