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doi: 10.1111/j.1526-4610.2005.05044.x 4

Cell 186:693714

At this condition, body cannot detoxify itself over long periods and the ROS keeps on increasing continuously, leading to an oxidative stress condition

doi: 10.1016/j.neuint.2015.01.008

As such, they are typically reserved for younger patients without cognitive impairment, given their significant risk of neuropsychiatric and cognitive side effects [88]