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Description

In order to test the induction of oxidative stress by FA more thoroughly, we incorporated the genetically-encoded cytosolic sensor roGFP

Knickelbein et al., 2015

In brief, two blinded investigators evaluated the sum of histological evidence of leukocyte influx in both alveolar and interstitial spaces, proteinaceous debris, formation of hyaline membranes and alveolar septal thickening, then weighted the variables according to their relevance in reflecting the lung damage