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(3) This receptor blockade results in localized bronchodilation, reduced airway resistance, and decreased bronchial gland secretions, improving airflow in constricted airways

Expression and functions of the CB2R receptor in human leukocytes

The study further revealed that exosomes with Nano-SDF suppressed the expression of Toll-like receptor 4 and its downstream signaling pathway, including NF-k and IL-1, thereby mitigating reactive gliosis at the injury site

These processes are central to the pathogenesis of a wide range of NDDs, including Alzheimers disease (AD), Parkinsons disease (PD), primary tauopathies (e.g., progressive supranuclear palsy [PSP], corticobasal degeneration [CBD], tau-linked frontotemporal dementia [FTD-tau]), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), synucleinopathies (e.g., Lewy body dementia [LBD] and multiple system atrophy [MSA]), Huntingtons disease (HD) and related polyglutamine (polyQ) diseases (e.g., spinocerebellar ataxias [SCA]), and prion diseases (PrD)