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Interestingly, the evident modulation of apoptosis by H

Cd 2+ induces mitochondrial permeability transition pore opening, depleting ATP and amplifying ROS through electron transport chain uncoupling (78)

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Secondly, the identification of specific molecular targets and pathways through which AS-IV exerts its effects could facilitate the design of targeted clinical trials, allowing for a more precise understanding of its mechanisms of action

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The plasmid was then nucleofected into purified mature schizonts of Pf3 D7