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[PubMed: 2929565] (56 year old man and 37 year old woman developed acute liver failure after ingestion of bottle of Nyquil [420 mL: 14 g acetaminophen in 25% alcohol] over 1-3 days [bilirubin 1.3 and 12.5 mg/dL, AST 8285 and 2413 U/L, Alk P 249 and 53 U/L], both survived)

Most available studies are preclinical or conducted on small human samples, which limits the ability to conclusively state their long-term efficacy and safety

PMID 8719443

Federicia [22], who reviewed the treatment criteria followed in different studies, concluded oral administration to be effective, but recommended further work to confirm this

Methionine (15mg)