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The biomarker clusters with increased lactate, pyruvate, alanine, and sometimes tricarboxylic acid cycle (TCA) intermediates (Figure 5, group 1), suggest dysfunction of oxidative phosphorylation or the TCA cycle

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Multi-omics technologies applied to tuberculosis drug discovery

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[DOI] [PubMed] [Google Scholar] 696.Nakashima M, Sonoda K, Watanabe T

In addition, AS-IV has been shown in vitro to promote the inactivation of fibrotic effector connective tissue growth factor (CTGF) in rat renal fibroblasts (NRK-49F) treated with TGF-1, thereby inhibiting its downstream induction of ECM synthesis and further resisting renal fibrosis