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The cognitive and memory impairments exhibited by patients with AD are closely related to defects in cholinergic neurotransmission within the CNS, which are characterized by the reduced synthesis, transport, and release of acetylcholine in the brain, as well as a decrease in the expression levels of cholinergic receptors

Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM (2010) Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

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Cardoso BR, Duarte GBS, Reis BZ, Cozzolino SMF

Acids such as gluconic and malic are most often linked to this process (Kaur et al

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