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Overall, while some of these agents (such as roflumilast and chlorquinaldol) are existing drugs, many others, including plant extracts and peptides, are better described as bioactive compounds with metabolic regulatory effects rather than conventional pharmacological therapies

In addition, preclinical studies found that vitamin D works synergistically with multiple chemotherapy regimens (Ma 2010)

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(2) activation of conserved immune pathways (cGAS/STING, Th1 polarization) that bridge gut and tumor immunity