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Cagrilintide is the first long-acting amylin analog to reach Phase 3 trials, with fatty acid acylation enabling once-weekly dosing compared to the three-times-daily dosing required by the older amylin analog pramlintide

For arthritis specifically, it helps reduce pain while encouraging regeneration of connective tissue

Kahle, P

Tendons are notoriously slow to adapt and slow to heal compared with more vascular tissues

10.1007/s10162-009-0158-y 41 OuH

Cagrilintide is a 39amino-acid peptide with structural modifications (including an N-terminal fatty diacid chain) designed to improve stability and reduce fibril formation compared with native amylin