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Down-regulating TXNRD3 may help explain COVID-19-associated orchitis (Reference Xu, Qi and Chi75) or gastrointestinal manifestations since suppression of TXNRD3 promotes colitis (Reference Liu, Du and Zhu76)

Autoimmune complications, which can also affect the pituitary gland, are a side effect of such treatment

The ability of auranofin-loaded chitosan-lipid hybrid nanoparticles (AUF-CLHNPs) to modulate GSK-3/Nrf2/HO-1 signaling pathways in a rotenone-induced PD model was studied and it was found that AUF-CLHNPs significantly improved auranofins brain penetration, overcoming its limited natural bioavailability