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In addition to the inadequate availability of glucose for use by neurons, the mitochondrial dysfunction and dysregulated glycolysis that occur in AD inhibit oxidative phosphorylation and result in decreased tricarboxylic acid substrates required for the synthesis of neurotransmitters, such as GABA and acetylcholine, further contributing to the pathology of this disease [58, 60, 61]

These results are consistent with a possible preventive effect of melatonin in the context of the COVID-19 pandemic

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The gut microbiome's role is highlighted in its ability to produce antioxidative enzymes and metabolites, which contribute to maintaining redox balance