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The satiety produced by amylin analogues tends to reduce caloric intake without the extreme food aversion that sometimes occurs with high-dose GLP-1 agonists, which can lead to inadequate protein intake and subsequent muscle loss

Link Akhondzadeh, S., et al

Commonly Reported Side Effects Based on community reports, side effects appear relatively uncommon and typically mild: Most Frequently Reported: Injection site reactions (redness, minor pain, itching) Mild nausea (particularly with oral administration) Temporary dizziness Headache Fatigue Less Commonly Reported: Skin flushing Changes in appetite Temporary mood changes Vivid dreams Theoretical Concerns Growth Factor Effects: BPC-157's upregulation of growth factors raises theoretical concerns for: Cancer promotion in those with existing malignancies Acceleration of undiagnosed tumors Effects on benign growths (polyps, fibroids) No evidence directly supports these concerns, but caution is warranted given the mechanisms involved

The 5mg vial also makes sense for people testing semaglutide for the first time

Escalation phase (roughly weeks 520): step up about every four weeks 5 7.5 10 12.5 15 mg but only as tolerated

SURMOUNT-5: Tirzepatide vs