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Fresenius Environ Bull 24:40594066 Zafar H, Ali S (2013) Boron inhibits the proliferating cell nuclear antigen index, molybdenum containing proteins and ameliorates oxidative stress in hepatocellular carcinoma

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Progressive VEGFAinduced RPE and photoreceptor degeneration and decline in visual function are mediated in part by NLRP3 inflammasomedependent IL1 activation and can be inhibited by targeting Nlrp3, caspase1/caspase11, or Il1r1 VEGFA hyper mice develop progressive basal laminar subRPE deposits and degeneration of the RPE and photoreceptors, resembling aspects of nonexudative AMD (Fig 9B and Appendix Figs S2 and S3)

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Yet in-vivo work in which the E-domain was expressed as part of an IGF-I isoform found that E-peptide-driven hypertrophy did depend on the IGF-1 receptor, while some individual gene responses did not