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doi: 10.1002/med.21653 [DOI] [PubMed] [Google Scholar] 322

Standard oral glutathione has a very low "bioavailability." In the digestive tract, an enzyme called gamma-glutamyl transpeptidase breaks down the glutathione molecule into its individual amino acids before it can be absorbed as a whole

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It binds to its receptors, initiating the phosphorylation of various downstream substrates, such as insulin receptor substrate (IRS)-1, -2, -3, and -4, thereby activating the insulin signaling pathway [29]

ClinicalTrials.gov identifier NCT00267527

Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites