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It was found that vacation periods reversed hypomethylation accumulated during NSW, particularly in genes involved in glutamatergic neurotransmission and immune pathways, including CREB1, CAMK2B, and GRIN2C, highlighting the plasticity of epigenetic landscape in response to circadian stress and recovery 235

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This overall survival compares favourably to a 3-year overall survival of less than 5%, which is mostly observed for patients receiving systemic therapy alone 290

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Therefore, in the process of developing ferroptosis-related drugs with the potential to target endometriosis, a series of downstream reactions caused by ferroptosis in ectopic endometrial tissue should be considered, and these issues need to be further resolved in the future