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The major clinical symptoms include dementia, apathy, social withdrawal, mood swings, depression, disturbed sleep, and delusions

The ubiquitinated forms of KCNN3, as well as the immunoprecipitated pull-down proteins, were detected by western blotting using anti-HA antibody, anti-ubiquitin antibody, or anti-KCNN3 antibody coupled with other labeling antibodies

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AMPK Activators: mechanisms of action and physiological activities

The measurements were performed with a CytoFlex flow cytometer (Beckman Coulter Inc, Brea, California, USA) using the CytExpert program

Melatonin protects the electron transport chain (ETC) by binding to the Fe-S cluster of NADPH dehydrogenase, reducing the generation of superoxide anion radicals (O2) caused by electron leakage, blocking the opening of the mitochondrial permeability transition pore (mPTP), and preventing apoptosis caused by cytochrome C leakage (Hardeland, 2017