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In addition, oxygen-evoked regulation of HIF-1 and NF-B is closely coupled with the intracellular redox state, such that modulating redox equilibrium affects their responsiveness at the molecular level (expression/transactivation)

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This disruption causes diminished release of lyso-phospholipids and lowered esterification of cholesterol, which increases the bioavailability of this latter and could explain the over-production of other derivatives (i.e., steroid hormones, bile acids), as aforementioned