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This peptide has demonstrated protective effects in preclinical models of heart failure, neurodegenerative disease, and agerelated muscle atrophy, and received FDA accelerated approval in 2025 as the first treatment for Barth syndrome [3]

Biochim Biophys Acta Mol Cell Res (2021) 1868(1):118877

41 Many factors that normally stimulate ET-1 synthesis, (for example, thrombin and AT-II) also cause the release of vasodilators, such as prostacyclin (PGI 2 ) and/or NO, which oppose the vasoconstricting function of ET-1

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In the manipulation (CT) group, however, the spontaneous activity level recovered gradually from Days 1 to 4, and it was significantly higher than in the manipulation (V) group on Day 4

Food and Drug Administration (FDA) for medical use in humans