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Preclinical euglycaemic clamp data showed no impairment of insulin sensitivity at therapeutic doses

doi: 10.1016/j.cell.2021.05.039 204 HilliganKLNamasivayamSClancyCSOMardDOlandSDRobertsonSJet al

These effects lead to hippocampus-dependent cognitive loss, including difficulties with spatial learning and memory, as well as neurodegeneration, inflammation, and synaptic malfunction

IFN- acts on the IFN- receptor, resulting in the phosphorylation of JAK1/2, which triggers the phosphorylation of STAT1 and leads to an increase in interferon regulatory factor 1 (IRF1) expression, which inhibits the function of SLC7A11 with SLC3A2 (system Xc ), ultimately leading to ferroptosis (61)

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With Travis Craddock and Nancy Klimas uncovering evidence of a possible genetic vulnerability in the mucous membranes of the nose which could potentially explain much in ME/CFS, the nose is becoming an ever more interesting place (blog coming up.) If youve tried intranasal preparations of glutathione, insulin or another substance, please let us know how it went.