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To demonstrate the advantages of bivalent target binding through the full IgG format for enhancing avidity and selectivity, compared to most clinically approved bispecific T cell engagers that rely on monovalent binding, we introduced mutations (H91A and Y92A) in the complementarity-determining regions of Her2 to generate Her2 variants with reduced target binding affinity

Winter ME (ed) (2003) Basic clinical pharmacokinetics, 4th edn

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GHK-Cu is a naturally occurring peptide found in human plasma, saliva, and urine

Ataga, K

Areas of research interest Technical specifications Compound Information Endogenous tripeptide thiol (antioxidant cofactor) Storage & Stability Lyophilized (powder) -20C long-term stable in sealed lyophilized form Reconstituted 2-8C use within 30 days of reconstitution Light Protect from light during storage and reconstitution Room temperature Short-term tolerant during shipping