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Anemia-Related Symptoms Fatigue Weakness Muscle weakness Pale/yellowed skin Rapid heartbeat Heart palpitations Shortness of breath Swollen/sore/smooth tongue Headaches Nausea Diarrhea Indigestion Incontinence Appetite problems Weight gain or weight loss Dizziness or faint feeling Nerve-Related Symptoms Nerve problems, such as tingling or numbness Mental health issues, such as depression Memory loss Dizziness Confusion Dementia Imbalance/trouble walking or standing Irritability Vision loss What Causes B12 Deficiency

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This efficacy differential highlights an important trade-off in the oral GLP-1 space: orforglipron offers the convenience of oral administration and freedom from injection but, based on current data, produces somewhat less weight loss than the most potent injectable multi-receptor agonists

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