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SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

doi: 10.3389/fphar.2024.1402138 96 LaferrreBHartABBowersCY

Why it matters for body composition: Tesofensine not only reduces caloric intake by controlling hunger but also ramps up basal metabolic rate , making it easier to burn fat while preserving lean muscle, especially when combined with a structured strength training plan

Using metabolomics, stable isotope tracing and transcriptomic data, the authors showed that cold-adapted BAT rapidly synthesizes fatty acids and acyl-carnitine from glucose