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Dimethyl fumarate (DMF), an FDA-approved drug prescribed for the treatment of multiple sclerosis (56), activates NRF2 by disrupting its interaction with KEAP1 ( Figure 7A ), allowing NRF2 to translocate to the nucleus and become transcriptionally active (57)

Christie DA, Kirchhof MG, Vardhana S, Dustin ML, Madrenas J

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