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GLP-1 receptor agonists cause fatigue primarily through indirect mechanisms including substantial caloric restriction from appetite suppression, gastrointestinal side effects leading to dehydration and nutritional deficits, and metabolic adaptation during weight loss

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If you have had gastric bypass or other weight-loss surgeries, your bodys ability to produce intrinsic factor may be diminished

Interactions Between Genetic, Lifestyle and Environmental Risk Factors for Multiple Sclerosis

Wang, Haiyan, et al

e-pub ahead of print 1990/05/01