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Several studies have demonstrated that in vitro heat stress has detrimental effects on various aspects of cytoplasmic and nuclear oocyte maturation 70 , including cytoskeletal rearrangement 14 , meiotic spindle formation 14,67 and early embryonic mitotic failure 71

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I-DXd is currently being evaluated in a phase II clinical trial of patients with previously treated SCLC (NCT05280470)

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