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Peptide drugs have been FDA-approved for decades, across dozens of therapeutic categories, from diabetes management to HIV-associated lipodystrophy to rare mitochondrial disorders

By the same time, the FDA approved the use of a equimolar combination of IGF-1 and IGFBP-3 (Mecasermin Rinfabate, iPlex), suggesting that it would be a better choice, seeming as it will require lower doses because of the augmented half-life of the molecule and buffering effect on concentration

Subsequent studies examined its breakdown into shorter C-terminally truncated metabolites

Contamination, mis-dosing, and degradation are real practical risks separate from the molecule itself

However, there are also risks and side effects associated with this surgery

Vitamin B12 deficiency occurs when a lack of vitamin B12 or folate causes the body to produce abnormally large red blood cells that cannot function properly