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Common medications including acetaminophen, statins, and certain antibiotics significantly deplete glutathione reserves during their hepatic processing

2.5 Altered autophagy mechanism (and role of GBA1 gene) Autophagy is a process that in normal conditions maintains cellular balance by recycling proteins and organelles, and acts as an adaptive mechanism that helps cells survive under stressful conditions

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Astrocytes actively influence pathogenesis through functional receptors and the release of signaling molecules

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Nature (2014) 506:18590.10.1038/nature12975 25 NurnbergerJIJrKollerDLJungJEdenbergHJForoudTGuellaIet alIdentification of pathways for bipolar disorder: a meta-analysis