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For the normally distributed data, we performed a parametric test to compare two groups

(Nature Communications) demonstrated that selective NNMT inhibition in diet-induced obese mice produced significant reductions in fat mass and improvements in insulin sensitivity without caloric restriction

YW, QL, YZ, LC, and YD completed the figures and the tables

For semaglutide, the main concerns include pancreatitis (rare but documented), gallbladder events (including gallstones, particularly during rapid weight loss), and a theoretical concern about medullary thyroid carcinoma based on rodent studies

Int Rev Cytol 234:201262 Pessi G, Ahrens CH, Rehrauer H, Lindemann A, Hauser F, Fischer HM, Hennecke H (2007) Genome-wide transcript analysis of Bradyrhizobium japonicum bacteroids in soybean root nodules

Cell Metab (2020) 32:15475