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In db/db mice, previous studies found that AMPK activation could reduce ROS production and increase mitochondrial biogenesis and ETC activity to alleviate kidney damage in diabetic models[150, 151]

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Tenuifolin directly impacts synaptic status (Koganezawa et al., 2021), increasing the total length and intersection numbers of dendrites in hippocampal CA1 neurons, notably affecting only female mice (Kong et al., 2024)