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This review validates various ferroptosis inhibition strategies (including NRF2 activation) through drug repurposing and novel agents, all of which have yielded suboptimal outcomes

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CuAAC involves the use of copper (Cu(I)) catalysts to enhance the reaction rate and regioselectivity toward the 1,4-substituted ring, avoiding the generation of a mixture of regioisomers that could affect the chemical and biological properties of the heterocycle (Du et al., 2021)

WAT works primarily as an endocrine organ that secretes hormones such as cytokines, leptin, and secretory factors (TNF-, IL-6, angiotensinogen, plasminogen activator inhibitor-1, IGF-1,adipsin and adiponectin)