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When compared to the vehicle control, transcranial application of P2RY12 or P2RX4 receptor antagonists impeded the ability of microglia (green) to assume both honeycomb and jellyfish morphologies, whereas P2RY6 antagonism blocked the formation of jellyfish processes only

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In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight

Weight regain patterns Clinical data from GLP-1 receptor agonist discontinuation studies consistently shows weight regain after stopping treatment

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Interestingly, these IL17-producing T cells may have a double-sided capacity, as they have also been shown to be necessary for standard short-term memory and cognition, implicating the complex and multifaceted role of meningeal T cells in healthy and inflamed CNS microenvironments [58]