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Although many studies have shown that GDNF can promote longdistance regeneration of axons after spinal cord injuries, the uncontrolled expression of GDNF may have side effects owing to an excessive axonal growth, aberrant sprouting, and axonal entrapment resulting in a pathological hypertrophy of the injured nerve (Eggers et al., 2019)

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In cerebral hemorrhage, CHAC1 helps mitigate inflammation and neuronal damage by inhibiting the Notch1 signaling pathway, reducing cell death and secondary brain injury

Quantitative real-time PCR Total RNA was extracted from homogenized tissue or cell culture and reverse transcribed as described previously (Schleicher et al, 2016)

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Proc Pacific Coast Surg Assoc, 1996