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In metastatic RCC, CB-839 plus Cabozantinib achieved a 42% ORR and 100% DCR (NCT02071862), 462 with Phase II trials ongoing (NCT0342821)

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Polymerization of 2-vinylpyridine is liable to occur under light or heat, therefore, 4-tert-butyl catechol of 0.1% is usually added to 2-vinylpyridine during storage to prevent it from polymerization

One way to treat this condition is via blood transfusion