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p = 0.003), and reduced tibial cortical thickness (ETD: -1.8%

Neurons, along with other high-energy-demand cells, are highly reliant on mitochondrial energy production, and inadequate ATP levels may compromise the efficiency of synaptic transmission (70), Furthermore, insufficient ATP activates a cellular stress response via the AMP-activated protein kinase (AMPK) signaling pathway (71, 72), suppressing non-essential metabolic processes (73), regulating mitochondrial biogenesis, and modulating autophagy (74) to conserve energy resources

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Montrief T, Koyfman A, Long B

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Night shift work and immune response to the meningococcal conjugate vaccine in healthy workers: a proof of concept study