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Indeed, PEDF-R binding and neurotrophic activity of PEDF have been shown to be provided by its 44-mer fragment spanning amino acid residues at positions 78121 70,83,84,85

Lack of a cooperativity on di-ubiquitin is likely because di-ubiquitin is too short to engage with all three proteins simultaneously

Vitamins: Vitamins have diverse biochemical functions

The photosynthetic process and photorespiration are the main sources of ROS and H 2 O 2 in physiological conditions [3, 8], and a battery of ROS scavengers keep these molecules under a strict control [5]