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J Clin Med 9:966

These neuroprotective properties have significant implications for developing treatments for neurodegenerative diseases, protecting brain tissue following injury, and understanding how growth factor signaling contributes to neuronal resilience in aging and disease contexts

Anti-inflammatory effects were also reported by the downregulation of neutrophil L-selectin (SELL) and elastase (ELANE), which are associated with neutrophil accumulation and the development of chronic skin wounds ( Estrogen was also shown to play a crucial role in controlling oxidative stress, a major contributor to impaired wound healing, by increasing the production of antioxidants, such as superoxide dismutase (SOD), and promoting B-cell lymphoma 2 (BCL2) expression, via activation of the nuclear factor erythroid 2-related factor (NRF2) (Kanda and Watanabe, 2003

These processes lead to measurable changes in circulating molecules such as D-dimer, fibrinogen, von Willebrand factor, matrix metalloproteinases, and endothelial adhesion markers (48)

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J Biol Chem 279(29):3036930374 Li J, Zhu H, Shen E, Wan L, Arnold JMO, Peng T (2010) Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes