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Preclinical research indicates GHK-Cu has the capacity to modulate the expression of over 4,000 human genes, according to bioinformatics analyses conducted by Pickart and colleagues, with a substantial subset of these genes tied directly to extracellular matrix maintenance, collagen production, and tissue-repair signaling

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RNA interference and drug treatments Small interfering RNAs (siRNAs) were custom-designed and purchased from SigmaAldrich (Supplementary Dataset 4)

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