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Role of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-beta1 activity

Therapeutic promise lies in phase-specific interventions: targeting acute lipid droplet dynamics, fine-tuning subacute SFA balance to counter ALOX15/GPX4-dependent peroxidation, which propagates membrane damage via Fenton chemistry, or intercepting pro-inflammatory mediators [177, 178]