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In parallel, several in vitro studies have suggested that DMF is cytotoxic to a variety of cancer cell lines (3437)

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We and others have reported that ceramides affect mitochondria function favoring changes in membrane chemical composition, inhibition of the respiratory chain, overproduction of ROS reducing intracellular ATP production and causing oxidative stress and mitophagy in brain (Camacho-Morales et al., 2024)

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