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T 3 also has profound impacts on mitochondrial function and turnover by regulating processes such as mitogenesis, proton leak, oxidative phosphorylation (OXPHOS), ROS generation [164, 165], autophagy, and -oxidation [166, 167]

AnandPKunnumakaraABSundaramCHarikumarKBTharakanSTLaiOSet alCancer is a preventable disease that requires major lifestyle changes

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These findings, together with the widespread expression of UBE3A in mammalian tissues including the SCN, suggest a conserved role for UBE3A in circadian timekeeping across species (Tian et al., 2011