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J Neurosci 25 : 57505756

In animal studies, doses are typically scaled by body weight at approximately 110 mcg/kg

387,388 These epigenetic changes contribute to the activation of pathogenic pathways involved in DPN

2006 Mar;91(3):799-805

In Th17 cells in particular, IGF-1 signaling also reduces mitochondrial membrane potential and reduce ROS production, which is particularly damaging to Th17 cells