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A population of cells with stem cell properties (glioblastoma stem cells, GSCs) drives the initiation and progression of GBM and is localized in specialized microenvironments which support their behavior

In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later

Docking of SlGSTU5 (receptor) with safeners (ligand) was carried out using autodock_vina_1_1_2_win32.msi [50] and MGLTools_win32_1.5.6 [51]

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